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Glucose promotes cancer

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Glucose promotes epithelial‐mesenchymal transitions in ...

Due to the high‐glucose consumption of cancer cells, cancer progression is positively associated with impaired energy metabolism. 19 T2D is characterized by high blood glucose levels and is positively correlated with the initiation, promotion and progression of various human cancers. 7, 8 High‐glucose levels can impair angiotensinogen and ...

Active: 2020-11-11

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High glucose promotes pancreatic cancer cells to escape ...

High glucose reduces NK cell-mediated lysis of pancreatic cancer cells by inhibiting cell surface MICA/B expression. In order to investigate the effect of high glucose on the killing effect of NK cells on pancreatic cancer cells, we co-cultured NK cells (Effector) with two pancreatic cancer cell lines, PANC-1 and SW1990 (Target) in media with different concentrations of glucose.

Active: 2021-02-08

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Here's How Sugar Might Fuel the Growth of Cancer

Some sugars are vital nutrients, and the body uses a form of sugar called glucose to generate energy. Cohen’s team found that fructose, in particular, affects a metabolic process (or pathway ...

Active: 2021-02-24

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(PDF) Glucose promotes epithelial‐mesenchymal transitions ...

Glucose promotes epithelial‐mesenchymal transitions in bladder cancer by regulating the functions of YAP1 and TAZ July 2020 Journal of Cellular and Molecular Medicine 24(18)

Active: 2020-12-23

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Glucose-dependent acetylation of Rictor promotes targeted ...

Cancer cells reprogram their metabolism in response to growth factor receptor mutations. However, the effect of altered nutrient levels on oncogenic signaling and therapeutic response is not well understood. We demonstrate that glucose or acetate, two abundant “fuel” sources in the brain, promote epidermal growth factor receptor vIII (EGFRvIII)-dependent signaling through activation of ...

Active: 2020-07-24

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CRKL promotes hepatocarcinoma through enhancing glucose ...

The glycolytic pathway contains a series of 10 reactions, and the enzymes involved in the glycolysis are all potential targets for inhibitors used in anti‐cancer therapy. 31 During the first step of glycolysis, glucose is transformed into glucose‐6 phosphate through the phosphorylation of the 6‐hydroxyl group of glucose by the enzyme ...

Active: 2021-02-24

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Glucose Transporter 1 Promotes the ... - Journal of Cancer

Abstract. Background: Glucose transporter 1 (GLUT1) is the main factor of Warburg effect, which is associated with poor prognosis in many tumors.However, the underlying molecular mechanism of GLUT1 in the progression of non-small cell lung cancer (NSCLC) is unclear. Methods: We used quantitative real-time PCR to detect GLUT1 mRNA expression in bronchial brushing samples and performed Western ...

Active: 2020-11-13

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Hyperglycemia, a Neglected Factor during Cancer Progression

Recent evidence from large cohort studies suggests that there exists a higher cancer incidence in people with type 2 diabetes (DM2). However, to date, the potential reasons for this association remain unclear. Hyperglycemia, the most important feature of diabetes, may be responsible for the excess glucose supply for these glucose-hungry cells, and it contributes to apoptosis resistance ...

Active: 2021-02-24

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S1PR3–G12-biased agonist ALESIA targets cancer metabolism ...

Toyomoto et al. demonstrate that ALESIA is a type of biased agonist targeting the S1PR3–G12 signaling pathway that can induce cancer-specific glucose starvation. This discovery highlights the possible existence of an endogenous biased ligand that modulates signaling in four major families of heterotrimeric G protein.

Active: 2021-02-23

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Blocking the IGF2BP1-promoted glucose metabolism of colon ...

Introduction. Colorectal cancer (CRC), a leading cause of cancer-related deaths worldwide, is a commonly diagnosed cancer with poor prognosis and high mortality rate. 1, 2 Currently, surgery is considered the primary therapeutic approach against colon cancer. 3 In addition, radiotherapy, chemotherapy, and the implementation of neoadjuvant therapy are also promising approaches for patients with ...

Active: 2021-02-15

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Cancer and Diet 101: How What You Eat Can Influence Cancer

Cancer is one of the leading causes of death worldwide ().But studies suggest that simple lifestyle changes, such as following a healthy diet, could prevent 30–50% of all cancers (2, 3).Growing ...

Active: 2021-02-19

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Cancer and Glycolysis - The Warburg Effect Explained ...

High blood glucose has been shown to accelerate cancer proliferation in vitro, while glucose deprivation has led to their death. Lower blood glucose in late-stage cancer patients is correlated with better health outcomes. In 2008, a group of scientists found that the tumor M2-PK, a form of a pyruvate kinase enzyme, causes the Warburg Effect.

Active: 2021-02-23

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Lactate promotes resistance to glucose starvation via ...

The glucose concentration in the medium was 25 mM, unless otherwise stated. For the glucose-starvation experiment, we mixed no-glucose DMEM (cat. no. 11966-025) or RPMI-1640 (cat. no. 11879-020) (both from Gibco) with the complete medium mentioned above in a certain proportion to make the glucose concentration 5 mM.

Active: 2021-02-11

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Autocrine INSL5 promotes tumor progression and glycolysis ...

Autocrine INSL5 promotes tumor progression and ... metabolic shift toward aerobic glycolysis enables cancer cells to convert glucose more efficiently into macromolecules, which are needed for rapid cell growth. On the one hand, cancer cells enhance ... promotion and hepatic glucose production (Grosse et al, 2014). A

Active: 2021-02-17

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High Glucose Level Promotes Migration Behavior of Breast ...

Background The diabetes patients have been associated with an increased risk of mortality by breast cancer and there are difference between the breast cancer patients with diabetes, and their nondiabetic counterparts in the regimen choice and effects of breast cancer treatment. However, the pathophysiological relationships of diabetes and breast cancer have not yet been elucidated in detail ...

Active: 2020-03-11

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Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis ...

Vitamin K2 promotes glycolysis and inhibits TCA cycle in bladder cancer cells. (A–D) Vitamin K2 time or dose-dependently affected the glucose consumption and lactate production in bladder cancer ...

Active: 2021-02-13

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CD44ICD promotes breast cancer stemness via PFKFB4 ...

CD44ICD promotes breast cancer stemness via PFKFB4-mediated glucose metabolism . Ruifang Gao 1, Dan Li 1, Jing Xun 1, Wei Zhou 1, Jun Li 1, Juan Wang 1, Chen Liu 2, Xiru Li 3, Wenzhi Shen 4, Huan Qiao 5, Dwayne G. Stupack 6 , Na Luo 1,7,8 . 1. School of Medicine, Nankai University, Tianjin 300071, China; 2.

Active: 2021-02-22

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High glucose level promotes migration behavior of breast ...

High glucose level promotes the migration of MCF-7 breast cancer cells. A confluent monolayer of MCF-7 cells was scratched and then cultured with normal (5.5 mM), high (25 mM) D-glucose concentration, or an osmotic control (5.5 mM D-glucose plus 19.5 mM D-mannitol or D-fructose) medium as described in the Materials and Methods.

Active: 2021-02-10

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[Full text] PRMT5 Promotes Aerobic Glycolysis and Invasion ...

Introduction. Breast cancer (BC) is a prevalent malignant tumor among women, whose incidence is gradually increasing in recent years with the changes of social environment and living habits. 1 With the progress of medical technology in recent years, the diagnosis and treatment of BC have been greatly improved. However, due to the proliferation and metastasis of breast cancer cells (BCCs ...

Active: 2021-02-01

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Targeting glucose metabolism for cancer therapy | Journal ...

Tumor cells exhibit high levels of glycolysis despite the presence of ample oxygen, a phenomenon termed aerobic glycolysis. This observation was first published by Warburg et al. (1924); it has since been supported by multiple studies in a variety of tumor types, and is now exploited in the clinic for diagnostic purposes.Positron emission tomography using 2-deoxy-2(18 F)-fluoro-D-glucose, a ...

Active: 2021-02-23

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