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Inflammation promotes cancer

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Expired: 2020-07-31 | from Hot Topic

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Inflammation as a tumor promoter in cancer induction

Acute inflammation usually counteracts cancer development, while chronic inflammation promotes cancer development. Just as inactivation of the p53 pathway may be universal in the neoplasia, the activation of the NFkappaB pathway may, conversely, be frequent in carcinogenesis, and a requirement for inflammation and promotion.

Active: 2020-08-23

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Inflammation and Cancer: Triggers, Mechanisms, and ...

Inflammation predisposes to the development of cancer and promotes all stages of tumorigenesis. Cancer cells, as well as surrounding stromal and inflammatory cells, engage in well-orchestrated reciprocal interactions to form an inflammatory tumor microenvironment (TME). Cells within the TME are highly plastic, continuously changing their phenotypic and functional characteristics.

Active: 2021-03-03

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A red meat-derived glycan promotes inflammation and cancer ...

red meat and cancer; N-glycolylneuraminic acid; tumor-associated inflammation; tumor-associated carbohydrate antigen; xenosialitis; There is a long-standing epidemiological link between the consumption of red meat (beef, pork, and lamb) and the incidence of carcinomas, atherosclerosis, type 2 diabetes, and all-cause mortality (1 ⇓ ⇓ –4).Although such diseases have multifactorial origins ...

Active: 2021-02-26

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Chronic Inflammation Promotes Skin Carcinogenesis in ...

To determine whether lupus inflammation is responsible for skin cancer promotion, we examined the effect of blocking inflammation with tacrolimus on skin tumorigenesis in MRL/lpr skin rash ().Animals were subjected to the skin carcinogenesis protocol and were randomized to receive intraperitoneal injection of 1 mg/kg tacrolimus or saline (carrier control) three times a week for 9 weeks.

Active: 2021-01-10

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‘Chemotherapy Promotes Inflammation, Causes Cancer To ...

Chemotherapy and radiation cause inflammation. The researchers suggest that chemo and radiation cause inflammation in the body, which contributes to cancerous tumors. The “unintended” consequence of these treatments is to cause cancer, not cure it. “In this study we demonstrate that chemotherapy-generated debris from dead and dying tumor cells can stimulate tumor growth, which has ...

Active: 2021-03-01

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Inflammation and cancer | Environmental Health and ...

Infection and inflammation account for approximately 25% of cancer-causing factors. Inflammation-related cancers are characterized by mutagenic DNA lesions, such as 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) and 8-nitroguanine. Our previous studies demonstrated the formation of 8-oxodG and 8-nitroguanine in the tissues of cancer and precancerous lesions due to infection (e.g ...

Active: 2021-03-02

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Targeting cancer-promoting inflammation — have anti ...

The immune system has crucial roles in cancer development and treatment. Whereas adaptive immunity can prevent or constrain cancer through immunosurveillance, innate immunity and inflammation ...

Active: 2021-03-05

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Nuclear IL‐33/SMAD signaling axis promotes cancer ...

Here, we demonstrate that nuclear IL‐33‐mediated activation of SMAD signaling pathway in epithelial cells is essential for cancer development in chronic inflammation. Using RNA and ChIP sequencing, we found that nuclear IL‐33 repressed the expression of an inhibitory SMAD, Smad6 , by interacting with its transcription factor, RUNX2.

Active: 2021-02-22

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Inflammation-induced IgE promotes epithelial hyperplasia ...

Epidermal hyperplasia and inflammation are hallmarks of a wide range of skin conditions. Furthermore, chronic inflammation may aid the proliferation and survival of EC harbouring genomic alterations, and so is now widely accepted to promote cancer development (Mantovani et al., 2008; Coussens et al., 2013; Grivennikov et al., 2010). Here, we ...

Active: 2021-02-28

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Cancer-related Inflammation - Cancer Research UK Barts Centre

Cancer-related inflammation is an important process contributing to malignant disease, with common and defined factors at different stages of progression. For many years we have known that extrinsic inflammatory pathways promote or, in some cases, initiate cancer i.e. that inflammation causes or promotes cancer.

Active: 2021-01-28

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PI3Kγ Activates Integrin α4 and Promotes Immune ...

Introduction. Chronic inflammation promotes tumor progression by stimulating angiogenesis and suppressing the antitumor immune response ().CD11b + Gr1 + immunosuppressive myeloid cells [myeloid-derived suppressor cells (MDSCs)] accumulate in the blood, spleen, lymph nodes, bone marrow, and tumor microenvironments in tumor-bearing animals and cancer patients ().

Active: 2021-03-04

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[PDF] RIPK3-Induced Inflammation by I-MDSCs Promotes ...

Myeloid-derived suppressor cells (MDSC) promote colorectal cancer by several mechanisms, including suppression of antitumor T cells and production of tumorigenic factors. We previously showed that an intermediate MDSC subset (I-MDSC) is expanded in an intestinal tumor model (ApcMin/+ mice), but the importance of this subset in promoting tumors is unclear. Here, we show that I-MDSCs are a ...

Active: 2021-02-03

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EMT and inflammation: inseparable actors of cancer ...

1 Introduction. While acute, transitory inflammation is an essential actor of tissue damage control and repair, tumor‐associated inflammation – which occurs in virtually all tumors – is of a chronic, unresolved type (Pesic and Greten, 2016) that fosters tumor progression.During tumorigenesis, cancer cells, innate immune cells [such as dendritic cells or tumor‐associated macrophages ...

Active: 2021-03-05

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The Hallmarks of Cancer 8: Tumor-Promoting Inflammation ...

The Hallmarks of Cancer 8: Tumor-Promoting Inflammation. The Hallmarks of Cancer are ten underlying principles shared by all cancers. You can read the first seven Hallmarks of Cancer articles here.

Active: 2021-03-01

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IL-17 Mediated Inflammation Promotes Tumor Growth and ...

The mechanism for inflammation associated tumor development is a central issue for tumor biology and immunology and remains to be fully elucidated. Although IL-17 is implicated in association with inflammation mediated carcinogenesis, mechanisms are largely elusive. In the current studies, we showed that IL-17 receptor-A gene deficient (IL-17R-/-) mice were resistant to chemical carcinogen ...

Active: 2020-07-30

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Loss of FFAR2 promotes colon cancer by epigenetic ...

Colonic epithelium and LP were isolated from these mice and cultured with or without 5 mM butyrate for 16 hr. mRNA expression of hdac2, sox17, and socs1 and promoter DNA methylation of sox17 and socs1 in colonic epithelium ( b) and colonic LP ( c) (WT: n = 6, FFAR2−/−: n = 6).

Active: 2020-04-01

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Cancer-related inflammation, the seventh hallmark of ...

Thus, the lack of a checkpoint (Tir8) of NF-kB activation leads to increased carcinogenesis in the gastrointestinal tract, underlying once more the connection between chronic inflammation and cancer promotion. In addition, Tir8 gene deficiency is associated with B cell lymphoproliferation and autoimmunity ( 23).

Active: 2021-03-02

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Hallmarks of Cancer: Tumor Promoting Inflammation

Hallmarks of Cancer: Tumor Promoting Inflammation Posted by Chris S on Aug 21, 2019 3:15:00 AM During a normal inflammatory response by the innate and adaptive immune system, immune cells carry out their designated task of engulfing and/or destroying foreign invaders.

Active: 2021-03-01

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Pseudomonas aeruginosa Stimulates Inflammation and ...

Inflammation triggered by innate immunity promotes carcinogenesis in cancer. Kaposi’s sarcoma (KS), a hyperproliferative and inflammatory tumor caused by Kaposi’s sarcoma-associated herpesvirus (KSHV) infection, is the most common cancer in AIDS patients. KSHV infection sensitizes cells to pathogen-associated molecular patterns (PAMPs). We examined the role of Pseudomonas aeruginosa, an ...

Active: 2021-03-03

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Inflammation and Colon Cancer - Gastroenterology

The connection between inflammation and tumorigenesis is well-established and in the last decade has received a great deal of supporting evidence from genetic, pharmacological, and epidemiological data. Inflammatory bowel disease is an important risk factor for the development of colon cancer. Inflammation is also likely to be involved with other forms of sporadic as well as heritable colon ...

Active: 2021-03-04

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