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Promote cancer metastasis

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Could Massage Therapy Promote CANCER

has been little progress in reducing cancer mortality in the last 30 years." 1 This statement, written more than a decade ago, still holds an unfortunate degree of truth, and explains why prognosis typically is based on degree of, or likelihood of, metastasis in a case. The majority of lethal cancers involve blood circulation metastasis.

Active: 2021-03-02

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Ral GTPases promote breast cancer metastasis by ...

The communication between tumor cells and their neighboring stromal cells is essential to sustain tumor growth and promote invasion and metastasis (Becker et al., 2016; Follain et al., 2020).Notably, this communication allows tumors to indoctrinate their microenvironment and switch the phenotypes of various cell types, such as endothelial cells, fibroblasts, or immune cells to the benefit of ...

Active: 2021-02-13

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Nrf2 Activation Promotes Lung Cancer Metastasis by ...

The impact of these mutations on the formation of metastasis in lung cancer patients has remained unclear. Nrf2 activation has been shown to promote cell migration in vitro ( Wang et al., 2016, Zhang et al., 2012) and metastasis in a hepatocellular carcinoma mouse model ( Zhang et al., 2015 ).

Active: 2021-03-02

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Molecular principles of metastasis: a hallmark of cancer ...

The proximity of breast cancer cells to neuronal synapses allows cancer cells to hijack N-methyl-d-aspartate receptor signaling to promote brain metastasis. 243 Protocadherin 7 is a protein that ...

Active: 2021-03-01

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Targeting Oncoimmune Drivers of Cancer Metastasis

Residual metastasis is a major cause of cancer-associated death. Recent advances in understanding the molecular basis of the epithelial–mesenchymal transition (EMT) and the related cancer stem cells (CSCs) have revealed the landscapes of cancer metastasis and are promising contributions to clinical treatments. However, this rarely leads to practical advances in the management of cancer in ...

Active: 2021-03-02

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c‐Myc promotes lymphatic metastasis of pancreatic ...

c‐Myc promotes lymphatic metastasis of pancreatic neuroendocrine tumor through VEGFC upregulation. Hui‐Jen Tsai, National Institute of Cancer Research, National Health Research Institutes, 1F No 367, Sheng‐Li Road, Tainan 70456, Taiwan.

Active: 2021-02-19

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Serpins Promote Cancer Cell Survival and Vascular Co ...

Brain metastasis is an ominous complication of cancer, yet most cancer cells that infiltrate the brain die of unknown causes. Here, we identify plasmin from the reactive brain stroma as a defense against metastatic invasion, and plasminogen activator (PA) inhibitory serpins in cancer cells as a shield against this defense.

Active: 2021-02-25

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OSA | Noninvasive and real-time monitoring of Au ...

Cancer is the second leading cause of mortality globally, while cancer metastasis, which accounts for about 90% of cancer-related mortality, presents an extremely poor prognosis. Thus, various nanomedicines were designed and synthesized for cancer treatment, but nanomaterials could lead to endothelial leakiness and consequently facilitate intravasation and extravasation of cancer cells to form ...

Active: 2021-03-04

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Cytochrome P450 Epoxygenase Promotes Human Cancer Metastasis

Cytochrome P 450 (CYP) epoxygenases convert arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EET), which exert diverse biological activities in a variety of systems. We previously reported that the CYP2J2 epoxygenase is overexpressed in human cancer tissues and cancer cell lines and that EETs enhance tumor growth, increase carcinoma cell proliferation, and prevent apoptosis of ...

Active: 2021-02-23

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Surgery and stress promote cancer metastasis: new outlooks ...

Surgery for the removal of a primary tumor presents an opportunity to eradicate cancer or arrest its progression, but is also believed to promote the outbreak of pre-existing micrometastases and the initiation of new metastases. These deleterious effects of surgery are mediated through various mecha …

Active: 2021-02-02

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FOXP3 promotes tumor growth and metastasis by activating ...

FOXP3 has been studied in several types of cancer cells [1,2,3,4,5,6,7].Most of these studies have shown the expression of FOXP3 is correlated with unfavourable prognosis, although there are some reports indicating the opposite role of FOXP3 [8, 9].In in vitro and in vivo studies, FOXP3 has been widely reported as a suppressor gene in breast cancer [7, 10,11,12] and prostate cancer [].

Active: 2021-02-27

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Myeloid-Derived Suppressor Cells Promote Metastasis in ...

Objective: To investigate the role of myeloid-derived suppressor cells (MDSC) in cancer progression after the stress of operative removal and the potential treatment value of MDSC depletion.Summary Background Data: Surgery is the most important treatment strategy in breast cancer. Recent research has provided evidence that operations may promote cancer metastases under some circumstances ...

Active: 2021-02-28

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Endothelial cells promote triple‐negative breast cancer ...

Triple‐negative breast cancer (TNBC) is a clinically important subgroup of breast cancers that, by definition, lack the expression of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (1, 2).The risk of distant recurrence and metastasis is substantially higher in patients with TNBC than in those with cancer other than TNBC ().

Active: 2021-02-04

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The novel lncRNA CALIC upregulates AXL to promote colon ...

CALIC /hnRNP‐L‐mediated upregulation of AXL is essential for the metastatic behavior of colon cancer cells. Since AXL plays critical roles in migration, invasion, and metastasis 17, 18, we investigated whether CALIC /hnRNP‐L‐mediated upregulation of AXL is responsible for the migratory activity of HCT116 cells.

Active: 2021-02-24

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Tumor-associated macrophages induce the expression of ...

Introduction. Gastric cancer (GC) is one of the most common malignancies, and is the second leading cause of cancer-related death worldwide ().Although rapid advancements in chemotherapy, radiation therapy, and gastric resection are widely used for GC patients, the 5-year overall survival rate has remained at ~28% owing to tumor metastasis (2,3).The tumor microenvironment (TME) is comprised of ...

Active: 2021-02-28

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Exosomes from Macrophages Exposed to ... - Journal of Cancer

Studies of human breast cancer metastasis using nude mice. Cancer metastasis reviews. 1990;8:285-97 42. Huang H, Zheng X, Cai C, Yao Z, Lu S, Meng X. et al. Exosomes derived from breast cancer lung metastasis subpopulations promote tumor self-seeding. Biochemical and biophysical research communications. 2018;503:242-8 43.

Active: 2021-03-01

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