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Promote cancer progression

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Expired: 2020-08-08 | from Biltmore

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Researchers discover specific molecules that promote ...

More information: Marco Napoli et al, Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation, Nature Communications (2020).DOI: 10 ...

Active: 2021-02-23

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Moffitt study uncovers how specific molecules promote ...

Moffitt study uncovers how specific molecules promote cancer progression. ... the activities of p53 and AKT to promote disease progression. ... migration and invasion and the promotion of tumor ...

Active: 2020-12-31

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Mcl-1 Interacts with Akt to Promote Lung Cancer Progression

Mcl-1 is a unique antiapoptotic Bcl2 family protein that functions as a gatekeeper in manipulating apoptosis and survival in cancer cells. Akt is an oncogenic kinase that regulates multiple cellular functions and its activity is significantly elevated in human cancers. Here we discovered a cross-talk between Mcl-1 and Akt in promoting lung cancer cell growth.

Active: 2021-02-23

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Tumor-initiating cells establish an IL-33–TGF-β niche ...

Cancer cells that give rise to solid tumors reside in a specialized microenvironment containing growth factors that support tumor growth and progression. The mechanisms by which tumor cells within this so-called “niche” attract and sustain these growth factors are poorly understood. Studying a mouse model of squamous cell carcinoma, Taniguchi et al. identified a signaling loop initiated by ...

Active: 2020-08-08

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SALL4 promotes gastric cancer progression via hexokinase ...

The stem cell factor SALL4 is reactivated in human cancers. SALL4 plays diverse roles in tumor growth, metastasis, and drug resistance, but its role in tumor metabolism has not been well characterized. The glycolytic levels of gastric cancer cells were detected by glucose uptake, lactate production, lactate dehydrogenase activity, ATP level, and hexokinase activity.

Active: 2021-01-15

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Cancer cell-secreted IGF2 instigates fibroblasts and bone ...

Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression. Nat. Commun. 8, 14399 doi: 10.1038/ncomms14399 (2017).

Active: 2021-02-22

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Lipids in the tumor microenvironment: From cancer ...

1. Introduction. Since Otto Warburg’s initial observation that cancer cells metabolize glucose in a manner different from their normal-tissue counterparts, it has been known that cancer cells have a unique metabolic profile [, , ].The metabolic requirements of cells as they develop from benign outgrowths to malignant and invasive cancerous lesions are complex and dynamic.

Active: 2021-02-12

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EGR1‐mediated linc01503 promotes cell cycle progression ...

Gastric cancer (GC) is the third leading cause of cancer‐related death worldwide and poses a great threat to the public health. 1 Based on the global cancer statistics in 2018, about 1.03 million GC cases and 0.78 million deaths were estimated in that year. 1 The high mortality from GC is mainly due to its advanced‐stage diagnosis, and thus ...

Active: 2021-02-21

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Moffitt Researchers Discover ... - Moffitt Cancer Center

TAMPA, Fla. — The development of cancer is a highly complicated process, involving multiple genes and signaling pathways that become upregulated or downregulated throughout different stages of tumor growth and spread.Two of the most commonly altered genes in cancer are p53 and AKT. In a new article published in the journal Nature Communications, Moffitt Cancer Center researchers describe how ...

Active: 2021-02-20

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Mesenchymal stem cell-derived CXCL16 promotes progression ...

Mesenchymal stem cell-derived CXCL16 promotes progression of gastric cancer cells by STAT3-mediated expression of Ror1 Cancer Sci . 2020 Apr;111(4):1254-1265. doi: 10.1111/cas.14339.

Active: 2021-02-09

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Moffitt Researchers Discover Specific Molecules that ...

This study was partly supported by funds from the National Cancer Institute (R35 CA197452, P30 CA076292, P30 CA125123, P30 ES030285), the Leukemia & Lymphoma Society, the Rita Allen Foundation ...

Active: 2021-01-08

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Moffitt researchers discover specific molecules that ...

Moffitt researchers discover specific molecules that promote cancer progression TAp63 regulates long noncoding RNA molecules that promote tumor development by activating AKT H. Lee Moffitt Cancer ...

Active: 2021-02-22

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Team Identifies Specific Molecules That Promote Cancer ...

Reference: Napoli M, Li X, Ackerman HD, et al. Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation. Nat Commun 2020;11(5156). doi: 10.1038/s41467-020-18973-w

Active: 2021-02-23

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Moffitt researchers discover specific molecules that ...

Moffitt researchers discover specific molecules that promote cancer progression 16 Oct 2020 The development of cancer is a highly complicated process, involving multiple genes and signaling pathways that become upregulated or downregulated throughout different stages of tumour growth and spread.

Active: 2020-10-16

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PKCλ/ι Loss Induces Autophagy, Oxidative ... - Cancer Cell

Yotaro et al. define a tumor suppressor role for PKCλ/ι in hepatocellular carcinoma (HCC). PKCλ/ι loss induces oxidative phosphorylation, reactive oxygen species production, and autophagy. These events activate an NRF2 transcriptional program that supports HCC progression.

Active: 2021-02-22

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(PDF) NEDDylation negatively regulates ERRβ expression to ...

ERRβ expression is regulated by NEDDylation and the SCF complex complex in breast cancer. a MCF7 cells were treated with varying concentrations of MLN4924 (0, 0.1, 0.3, 0.5 and 1.0 µM) for 24 h ...

Active: 2021-02-05

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SPT6 recruits SND1 to co‐activate human telomerase reverse ...

Numerous studies have demonstrated the involvement and promotion of hTERT in tumor progression by regulating various signaling pathways, cell factors, and cell functions [[12-16]]. In CRC, the expression of hTERT was shown to determine the metastatic phenotype of cancer cells [ [ 17 ] ] and to be related to the worse survival rates in patients ...

Active: 2021-02-07

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Moffitt researchers discover specific molecules that ...

Two of the most commonly altered genes in cancer are p53 and AKT. In a new article published in the journal Nature Communications, Moffitt Cancer Center, USA, researchers describe how the protein TAp63 controls levels of RNA molecules, which subsequently connects the activities of p53 and AKT to promote disease progression.

Active: 2021-01-27

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Researchers discover specific molecules that promote ...

The development of cancer is a highly complicated process, involving multiple genes and signaling pathways that become upregulated or downregulated throughout different stages of tumor growth and spread. Two of the most commonly altered genes in cancer are p53 and AKT. In a new article published in the journal Nature Communications, Moffitt Cancer Center researchers describe how the protein ...

Active: 2021-01-27

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Frontiers | Progression-Mediated Changes in Mitochondrial ...

Ovarian cancer is the deadliest gynecological cancer in women, with a survival rate of less than 30% when the cancer has spread throughout the peritoneal cavity. Aggregation of cancer cells increases their viability and metastatic potential; however, there are limited studies that correlate these functional changes to specific phenotypic alterations.

Active: 2021-02-23

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