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Promotes autophagy in cancer

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Expired: 2020-07-21 | from JD Williams

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Autophagy promotes immune evasion of pancreatic cancer by ...

Immune evasion is a major obstacle for cancer treatment. Common mechanisms of evasion include impaired antigen presentation caused by mutations or loss of heterozygosity of the major ...

Active: 2021-03-03

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Role of Autophagy in Cancer Prevention | Cancer Prevention ...

Macroautophagy (autophagy hereafter) is a catabolic process by which cells degrade intracellular components in lysosomes. This cellular garbage disposal and intracellular recycling system maintains cellular homeostasis by eliminating superfluous or damaged proteins and organelles and invading microbes and by providing substrates for energy generation and biosynthesis in stress.

Active: 2021-02-26

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Role of Autophagy in Cancer and Tumor Progression | IntechOpen

1.2.3. Upregulation of autophagy promotes resistance to cancer therapy. Autophagy may function to remove proteins or organelles that are damaged by cancer treatments or, through the degradation of cellular components, may provide nutrients for the rapidly growing cells.

Active: 2021-03-03

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JCI - The role for autophagy in cancer

Autophagy was initially thought to be a tumor-suppression mechanism. This concept derived from early reports that the essential autophagy gene ATG6/BECN1 was monoallelically lost in 40% to 75% of human prostate, breast, and ovarian cancers (13 – 15).Indeed, in certain cell-based assays, autophagy suppression promotes cancer cell growth, and Becn1 heterozygous mutant mice are prone to ...

Active: 2021-03-02

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Autophagy and autophagy-related proteins in cancer ...

Autophagy, as a type II programmed cell death, plays crucial roles with autophagy-related (ATG) proteins in cancer. Up to now, the dual role of autophagy both in cancer progression and inhibition remains controversial, in which the numerous ATG proteins and their core complexes including ULK1/2 kinase core complex, autophagy-specific class III PI3K complex, ATG9A trafficking system, ATG12 and ...

Active: 2021-03-03

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Frontiers | Mitophagy in Pancreatic Cancer | Oncology

Dysregulated autophagy promotes or inhibits the growth of pancreatic cancer by interfering with different metabolic pathways or tumor signals, such as carbohydrate metabolism, fatty acid β-oxidation, and amino acid transport ().For example, the reduced glycolysis gene PKM2 promotes survival by maintaining autophagy induced by low glucose in PDAC cells ().

Active: 2021-02-27

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G9a promotes cell proliferation and suppresses autophagy ...

However, basal autophagy contributes to the survival of cells in some cancers. In contrast, excessive induction of autophagy inhibits growth and proliferation of cancer cells (27, 28). It has been reported that G9a is highly expressed in GC (29, 30). However, the biologic function and molecular mechanism of G9a are not clear in regulating the ...

Active: 2021-02-27

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(PDF) Erb-b2 Receptor Tyrosine Kinase 2 (ERBB2) Promotes ...

PDF | The epidermal growth factor receptor (EGFR) family member erb-b2 receptor tyrosine kinase 2 (ERBB2) is overexpressed in many types of cancers... | Find, read and cite all the research you ...

Active: 2021-03-05

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IJMS | Special Issue : Autophagy in Cancer Progression and ...

The mechanism of autophagy is initiated by the creation of autophagosomes, which capture and encapsulate abnormal components. Afterward, autophagosomes assemble with lysosomes to recycle or remove degradative cargo. The regulation of autophagy has bipolar roles in cancer suppression and promotion in diverse cancers.

Active: 2021-02-27

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Role and mechanism of autophagy‐regulating factors in ...

Autophagy is a culprit involved in the development of multiple diseases like diabetes mellitus type II, neurological degeneration, cardiovascular diseases and cancer. 6 There are more than 30 autophagy‐related genes (ATG) that are involved in the regulation of autophagy. 4, 7 Monoallelic deletion of autophagy related genes (ATG7, ATG5) or ...

Active: 2021-02-28

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Autophagy and thyroid cancer - Journal of Cancer ...

Autophagy dependency is reportedly controlled by p53 status, RAS/RAF family status, JAK/STAT/PI3K signaling pathways, and so on. In fact, BRAF V600E promotes autophagy dependence in multiple tumors [37,102-104], presumably as do RAS and RET/PTC. Thus, thyroid cancers, most of them have mutant RAS/RAF or RET/PTC, likely depend on autophagy for ...

Active: 2021-03-03

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Autophagy Blockade Limits HER2+ Breast Cancer ...

HER2 amplifications act as driver mutations in about 25% of human breast cancer. Hao et al. show that disruption of autophagy abolishes mammary tumorigenesis by preventing the transport of oncogenic HER2 to the tumor cell surface, instead diverting it to small extracellular vesicles that release HER2 from the cell.

Active: 2021-03-03

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multiple roles of autophagy in cancer | Carcinogenesis ...

Autophagy and cancer. Autophagy is known to protect us against various forms of human disease . In some cases, for example neurodegenerative disease, it is clear that autophagy facilitates the removal of aggregate-prone proteins that lead to Huntington’s and Parkinson’s disease . The role of autophagy in cancer, however, is more complex.

Active: 2021-02-27

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The Importance of Autophagy Regulation in Breast Cancer ...

1. Introduction. Breast cancer (BC) is the most common and fatal cancer in women worldwide, despite decreasing mortality rates that result mostly from efficient screening strategies [1, 2].It has been estimated that approximately 1.3 million females develop BC each year, with around 465.000 expected to succumb to the disease [3, 4].BC is ranked in the second place in mortality among cancer ...

Active: 2017-01-25

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Autophagy inhibition of cancer stem cells promotes the ...

Lung cancer remains the most common cancer worldwide, and is the most common cause of cancer-related death. 1,2 Patients with lung cancer display poor prognosis with less than 20% of 5-year overall survival. 3 More than 50% of all lung cancers are non-small cell lung carcinoma (NSCLC), which accounts for the most common subtype. 4,5 In the clinic, strategies for NSCLC treatment range from ...

Active: 2020-11-14

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The Emerging Roles of Autophagy-Related MicroRNAs in Cancer

The microRNA-423-3p-Bim Axis Promotes Cancer Progression and Activates Oncogenic Autophagy in Gastric Cancer. Mol Ther. 2017;25:1027-37 118. Xu Z, Li Z, Wang W, Xia Y, He Z, Li B. et al. MIR-1265 regulates cellular proliferation and apoptosis by targeting calcium binding protein 39 in gastric cancer and, thereby, impairing oncogenic autophagy.

Active: 2021-03-02

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Down-regulation of OGT promotes cisplatin resistance by ...

Down-regulation of OGT promotes cisplatin resistance by inducing autophagy in ovarian cancer . Fuxing Zhou 1#, Xiaoshan Yang 2#, Hang Zhao 3#, Yu Liu 1, Yang Feng 4, Rui An 5, Xiaohui Lv 1, Jia Li 1 , Biliang Chen 1 . 1. Department of Gynecology and Obstetrics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China; 2.

Active: 2021-03-01

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Knockdown of RAB25 promotes autophagy and inhibits cell ...

Introduction. Ovarian cancer is the second most common gynecological malignancy and affects more than 200,000 women worldwide each year. The symptoms of ovarian cancer are non-specific and therefore two-thirds of cases are not diagnosed until the later stages ().Aggressive surgical reduction and new chemotherapeutic agents have improved the prognosis of advanced ovarian cancer (2,3); however ...

Active: 2020-12-26

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Cadmium promotes breast cancer cell proliferation ...

Cadmium (Cd), which is considered a carcinogenic metal, promotes breast cancer (BC) progression, but the precise mechanism remains unclear. Herein, MCF-7 and T47-D cells were treated with 0.1, 1, and 10 μM cadmium chloride (CdCl 2) for 24, 48 and 72 h.In our study, Cd exposure significantly accelerated the proliferation, migration and invasion of MCF-7 and T47-D cells.

Active: 2021-02-28

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Autophagy and p53 - CSHL P

Autophagy thereby promotes survival in starvation and prevents tissue degeneration. There is an important relationship between autophagy and p53. Autophagy suppresses p53 and also p53 activates autophagy. The suppression of p53 by autophagy is important for tumor promotion and likely also for preventing tissue degeneration.

Active: 2021-02-25

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