Tasin Specification

Listing Results Tasin Specification

Frequently Asked Questions

• Does tasin-1 kill dld1?

  Tasin-1 exerted its killing effects primarily by depleting cholesterol through inhibition of emopamil-binding protein (EBP) activity. However, knockdown of truncated APC (>90%) expression desensitized DLD1 cells to Tasin-1, suggesting that APC is required for Tasin-1’s cytotoxicity [1].

• Is tasin-1 a selective inhibitor of mutant Apc?

  Tasin-1 is a selective inhibitor of mutant APC. In two authentic human CRC cell lines HCT116 (WT APC) and DLD1 (truncated APC1417), Tasin-1 exhibited potent and selective toxicity toward DLD1 cells with IC50 value of 70 nM but not toward HCT116 cells (IC50 >50 μM). Tasin-1 also reduced the endogenous cholesterol biosynthesis rate.

• Does tasin-1 inhibit tumor growth in HCT116?

  Tasin-1 resulted in the appearance of apoptotic cells with fragmented nuclei and induced an increase in cleaved caspase 3 and cleaved PARP1. However, Tasin-1 did not inhibit tumor growth in HCT116 (WT APC) xenografts.

• What is the mechanism of action of tas1553?

  TAS1553, a novel class of RNR inhibitor, demonstrates synergistic antitumor efficacy in combination with nucleoside analogues [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics; 2019 Oct 26-30; Boston, MA.

• Is tas1553 a novel class of RNR inhibitors?

  Citation Format: Takuya Hoshino, Hiroyuki Ueno, Wakako Yano, Sayaka Tsukioka, Seiji Miyahara, Takamasa Suzuki, Kazutaka Miyadera, Teruhiro Utsugi, Takeshi Sagara. TAS1553, a novel class of RNR inhibitor, demonstrates synergistic antitumor efficacy in combination with nucleoside analogues [abstract].

• What is the difference between aromatase inhibitors and tamoxifen?

  Aromatase inhibitors tend to cause fewer serious side effects than tamoxifen, such as blood clots, stroke, and endometrial cancer. But aromatase inhibitors can cause more heart problems, more bone loss (osteoporosis), and more broken bones than tamoxifen, at least for the first few years of treatment.

• What is inhibitor of apoptosis proteins ?

  Inhibitor of apoptosis proteins (IAPs) is a class of key apoptosis regulators that promote cancer cell resistant to apoptosis, particularly in cancer treatment.